1. [Genetic structure and the load of hereditary diseases in five populations of Arkhangel'skaia region].
- Author
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Mamedova RA, El'chinova GI, Startseva EA, Kozlova SI, Petrin AN, Rudenskaia GE, Khlenikova OV, Mikhaĭlova LK, Efimova MN, Shchekotikhina IuA, Prokhorov AIu, Kadoshnikova MIu, Galkina VA, Brusintseva OV, and Ginter EK
- Subjects
- Consanguinity, Female, Genes, Dominant, Genes, Recessive, Genetic Linkage, Humans, Male, Rural Health, Siberia, Urban Health, X Chromosome, Genetic Diseases, Inborn genetics, Genetics, Medical, Genetics, Population
- Abstract
A population and medical genetic investigation was performed in a number of raions in the Arkhangel' skaya oblast. Random inbreeding coefficients were 0.000358 and 0.000361 in the Vinogradovskii and Krasnoborskii raions. Malecot's local inbreeding coefficients were 0.000565 and 0.000472, respectively. The endogamy indices were 0.37 and 0.54, respectively. In the urban population, the loads of autosomal dominant, autosomal recessive, and X-linked pathology were 1.01 and 0.98 per 1000 individuals, and 0.29 per 1000 men; in the rural population, they were 1.22, 1.55, and 1.08, respectively. In the populations studied, the hereditary pathology spectrum is described.
- Published
- 1996