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The characteristic of medical and dosimetric register database of Siberian Group of Chemical Enterprises personnel is represented. This characteristic includes the description of the database structure, main sources of information, quantitative composition of the cohort under study, methods of evaluation of the external and internal irradiation doses, modern data on cancer incidence and reasons of death. The database is the basis for estimating the risk of the cancer and non-cancer effects after a long-term radiation exposure and dependence of "dose-response" at different levels: from population and group to cell and molecular. Now the database of register contains the information about more than 66,500 employees at the Siberian Group of Chemical Enterprises, about 22,000 of whom were exposed to external irradiation and more than 7500 employees--to internal irradiation. The register is the information resource of a large biological material bank. Using this bank, the research of chronic radiation exposure genetic effects and markers of individual radio sensitivity is performed.

There was analyzed cancer mortality of residents of Seversk, located close to the world's largest complex of enterprises of the nuclear industry - the Siberian Chemical Enterprise (the period from 01.01.1970 till 31.12.2005 For comparison there were used rates of cancer mortality in the nearest town (Tomsk), similar in climate-geographical, economic and social conditions. The study found that cancer mortality of Seversk residents during the period 1970-2005 increased in 3.2 times (from 70.2 to 223.5 per 100,000). Among the causes of cancer mortality in men there were prevailed tumors of the digestive system as well as blood and lymphatic tissues. In women, the leading causes of death were tumors of the digestive system, the genitals and the breast. Standardized rates of cancer mortality in the Seversk population were lower than in residents of Tomsk, except female mortality due to hematological malignancies and malignant tumors of the urinary tract and genitals.

The article presents the results of analysis of dynamics of health indicators of population of industrial town (medical demographic indicators, disability, morbidity of social hygienically important diseases) during 1970-2010. The classified administrative territorial municipality of Seversk constructed near the Siberian chemical industrial center, the internationally first-rate complex of nuclear industry enterprises was used as a research base. It is demonstrated that dynamics of health indicators of studied population had such negative tendencies as rapid population ageing, population loss due to decrease of natality and increase of mortality (population of able-bodied age included), prevalence of cardio-vascular diseases, malignant neoplasms and external causes, chronization of diseases. The established tendencies are to be considered in management decision making targeted to support and promote population health in industrial towns.

The protection and promotion of population's health is a necessary condition for the provision of national security, stable economic growth and preservation of the Russian way of life. While working out the strategy of the protection and promotion of population's health, we analyzed the dynamics of the basic indicators of population's morbidity and also studied the self-estimation of health status and the personal medical activity of regional population. As a result of this, the increase in the prevalence of socially significant diseases against some reduction in the levels of primary and general morbidity was noted. The results of a sociological survey showed that personal medical activity of citizens is not high and ineffective, and factors indicated by respondents as reasons for ill health are potentially manageable. In this connection the preventive activity should be, first of all, aimed at changing the behavior of population in relation to one's own health and the minimization of the negative effect of manageable risk factors.