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Purpose: The role of adjuvant postmastectomy radiotherapy (PMRT) remains controversial for patients with pT3N0M0 breast cancer, especially when patients are treated with the updated adjuvant chemotherapy. Our study aimed to compare locoregional recurrence-free survival (LRFS), disease-free survival (DFS), and breast cancer-specific survival (BCSS) in pT3N0M0 patients with and without postmastectomy radiotherapy. Patients and Methods: Between October 2000 and 8 September 2016, the database of the Breast Cancer Center of Shanghai yielded 114 patients with node-negative non-metastatic breast cancer larger than 5 cm. Univariate and multivariate analyses were performed to assess the risk factors for survivals. Differences between the two groups were compared using the Log rank test. Results: Fifty-nine (51.8%) of the patients received adjuvant PMRT. The median follow-up was 62.3 months. Five-year LRFS was 100% in the PMRT group vs 98.1% in the non-PMRT group (P=0.17); 5-year DFS was 97.1% for the entire cohort, 98.0% for the PMRT group vs 96.2% for the non-PMRT group (P=0.18). Univariate analysis identified that family history of malignant tumors, lymphovascular invasion (LVI), or triple-negative breast cancer (TNBC) molecular subtype were associated with higher locoregional recurrence (LRR) (P< 0.05). No PMRT was the only risk factor independently associated with poorer DFS (P=0.048) on multivariate analysis. No difference in BCSS was observed between the two groups. Conclusion: The present study demonstrated a low LRR rate and good survival for node-negative breast cancer > 5 cm. Patients with family history of malignant tumors, TNBC subtype, LVI positivity, or grade 3 disease are at high risk for LRR and might benefit from PMRT. [ABSTRACT FROM AUTHOR]

Firms have a crucial role to play in driving the process of greenization, yet there exists a dearth of studies that have comprehensively examined the combined influence of external environmental regulation and corporate environmental commitment on corporate greenization. In this study, utilizing a database comprising Chinese firms listed on the Shenzhen and Shanghai Stock Exchanges between 2011 and 2019, an empirical analysis is conducted to investigate the effects of external environmental regulation, corporate environmental commitment, and their interaction on corporate greenization. Textual analysis is employed to quantitatively evaluate the extent of these two variables. The findings reveal that external environmental regulation exerts a positive impact on both corporate greenization input and output, whereas corporate environmental commitment only significantly enhances the output. Moreover, notable substitution effects are discovered between external environmental regulation and corporate environmental commitments concerning the greenization output. Further heterogeneity analysis uncovers that such substitution effects are predominantly observable in non-state-owned firms and those with relatively lower levels of pollution. These empirical outcomes provide valuable theoretical support for both the Chinese government and firms alike to advance and promote the progress of greenization. [ABSTRACT FROM AUTHOR]