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A study conducted by researchers at Shanghai Jiao Tong University in China explored the correlation between serum bilirubin levels and the therapeutic efficacy of EGFR tyrosine kinase inhibitors in patients with EGFR-mutated non-small cell lung cancer. The study found that elevated serum direct bilirubin and smoking status were significant prognostic factors for these patients, impacting overall survival rates. The research concluded that serum direct bilirubin and smoking status could serve as important biomarkers for prognosis in EGFR-mutated NSCLC patients undergoing EGFR-TKI therapy. [Extracted from the article]

Researchers from Fudan University in Shanghai, China, conducted a study on renal cell carcinoma patients to evaluate the outcomes of immunotherapy combined with tyrosine kinase inhibition based on cyclin-dependent kinase 5 (CDK5) expression levels. The study found that patients with low CDK5 expression had a higher response rate and longer progression-free survival compared to those with high CDK5 expression. The research suggests that CDK5 expression levels could serve as a biomarker to determine the most effective treatment strategy for these patients. The study was funded by various organizations, including the National Natural Science Foundation of China. [Extracted from the article]

A recent study conducted at Shanghai Normal University has introduced a new type of nitrogen-doped carbon dot (ET-CD) derived from ellagic acid and L-tyrosine for photothermal anticancer and anti-inflammation purposes. The ET-CD demonstrated high photothermal conversion efficiency and stability, effectively ablating tumor tissues while reducing inflammation in normal cells. This innovative therapeutic strategy shows promise for promoting the clinical application of photothermal therapy in cancer treatment. The research has been peer-reviewed and offers potential advancements in cancer therapy. [Extracted from the article]

A recent study conducted by Shanghai Ocean University in China has found that chronic stress can disrupt emotional and energetic balance, leading to abnormal behaviors such as binge eating. This behavior, known as emotional eating, can exacerbate emotional instability and contribute to obesity. The study used an animal model to investigate the role of tryptophan, an amino acid, in emotional eating. The results showed that tryptophan supplementation improved depression, anxiety-like behaviors, and abnormal eating behaviors, suggesting that the tryptophan-derived serotonin pathway plays a key role in emotional eating. The findings have implications for targeted therapy for stress-induced obesity. [Extracted from the article]

A study conducted at Shanghai General Hospital in China has found that propofol anesthesia administered to pregnant rats can impair the learning and memory function of their offspring. The researchers observed that the expression of brain-derived neuro-affecting factor and tyrosine kinase B in the hippocampus of the offspring decreased significantly. This suggests that the impairment may be caused by the inhibition of the brain-derived neuro-affecting factor/tyrosine kinase B pathway. The study highlights the potential effects of propofol anesthesia on cognitive function in offspring and provides valuable insights for further research in this area. [Extracted from the article]

A study conducted by researchers at Tongji University in Shanghai, China, has shed light on the molecular mechanisms behind drug resistance in non-small cell lung cancer (NSCLC) patients treated with tyrosine kinase inhibitors (TKIs). The study found that high levels of DNMT3A, an enzyme involved in DNA methylation, were associated with poor prognosis in NSCLC patients. The researchers also discovered that DNMT3A upregulated inhibitor of apoptosis proteins (IAPs), reducing the susceptibility of NSCLC cells to TKIs. Additionally, the study revealed that TKI-induced cellular senescence in DNMT3Ahigh cells was reversible, leading to tumor recurrence and growth. Blocking the DNMT3A/IAPs signals enhanced the efficacy of TKIs in NSCLC tumor-bearing mice. This research provides a promising strategy for the effective treatment of NSCLC. [Extracted from the article]

For more information on this research see: Tyrosine Kinase Receptor B Attenuates Liver Fibrosis By Inhibiting Tgf-beta/smad Signaling. Keywords: Shanghai; People's Republic of China; Asia; Amino Acids; Aromatic Amino Acids; Bioengineering; Biotechnology; Carbon Tetrachloride; Chemicals; Drugs and Therapies; Enzymes and Coenzymes; Gastroenterology; Gene Therapy; Health and Medicine; Hepatic Fibrosis; Kinase; Ligases; Liver Cirrhosis; Liver Diseases and Conditions; Liver Fibrosis; Proteins; Proteomics; Tyrosine; Tyrosine Kinase EN Shanghai People's Republic of China Asia Amino Acids Aromatic Amino Acids Bioengineering Biotechnology Carbon Tetrachloride Chemicals Drugs and Therapies Enzymes and Coenzymes Gastroenterology Gene Therapy Health and Medicine Hepatic Fibrosis Kinase Ligases Liver Cirrhosis Liver Diseases and Conditions Liver Fibrosis Proteins Proteomics Tyrosine Tyrosine Kinase 749 749 1 10/24/23 20231027 NES 231027 2023 OCT 27 (NewsRx) -- By a News Reporter-Staff News Editor at Gene Therapy Weekly -- A new study on Biotechnology - Gene Therapy is now available. [Extracted from the article]

Keywords: Shanghai; People's Republic of China; Asia; Amino Acids; Aromatic Amino Acids; Essential Amino Acids; Peptide Hormones; Peptide Proteins; Phenylalanine; Proinsulin; Risk and Prevention EN Shanghai People's Republic of China Asia Amino Acids Aromatic Amino Acids Essential Amino Acids Peptide Hormones Peptide Proteins Phenylalanine Proinsulin Risk and Prevention 975 975 1 08/28/23 20230901 NES 230901 2023 SEP 1 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on Peptide Proteins - Proinsulin. Keywords for this news article include: Shanghai, People's Republic of China, Asia, Amino Acids, Aromatic Amino Acids, Essential Amino Acids, Peptide Hormones, Peptide Proteins, Phenylalanine, Proinsulin, Risk and Prevention, Fudan University. Here, we report that phenylalanine modifies insulin receptor beta (IR beta) and inactivates insulin signaling and glucose uptake.". [Extracted from the article]

Metformin in turn reduced tryptophan uptake by colorectal cancer cells, thereby restoring tryptophan availability for CD8 & PLUSMN; T cells and increasing their cytotoxicity. Keywords: Shanghai; People's Republic of China; Asia; Amino Acids; Antidiabetic Agents; Aromatic Amino Acids; Biguanides; Cancer; Colon Cancer; Colorectal Research; Drugs and Therapies; Essential Amino Acids; Gastroenterology; Genetics; Health and Medicine; Hypoglycemic Agents; Metformin; Metformin Therapy; Non-Sulfonylureas; Oncology; Pharmaceuticals; Tryptophan EN Shanghai People's Republic of China Asia Amino Acids Antidiabetic Agents Aromatic Amino Acids Biguanides Cancer Colon Cancer Colorectal Research Drugs and Therapies Essential Amino Acids Gastroenterology Genetics Health and Medicine Hypoglycemic Agents Metformin Metformin Therapy Non-Sulfonylureas Oncology Pharmaceuticals Tryptophan 310 310 1 08/28/23 20230901 NES 230901 2023 AUG 29 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Fresh data on Oncology - Colon Cancer are presented in a new report. [Extracted from the article]

Keywords: Shanghai; People's Republic of China; Asia; Adverse Drug Reactions; Amino Acids; Aromatic Amino Acids; Cancer; Drugs and Therapies; Enzymes and Coenzymes; Health and Medicine; Hematology; Immunoproliferative Disorders; Kinase; Lymphatic Diseases and Conditions; Lymphoma; Lymphoproliferative Disorders; Oncology; Proteins; Proteomics; Tyrosine; Tyrosine Kinase EN Shanghai People's Republic of China Asia Adverse Drug Reactions Amino Acids Aromatic Amino Acids Cancer Drugs and Therapies Enzymes and Coenzymes Health and Medicine Hematology Immunoproliferative Disorders Kinase Lymphatic Diseases and Conditions Lymphoma Lymphoproliferative Disorders Oncology Proteins Proteomics Tyrosine Tyrosine Kinase 892 892 1 07/31/23 20230801 NES 230801 2023 AUG 1 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Current study results on Oncology - Lymphoma have been published. For more information on this research see: Expert Consensus of Management of Adverse Drug Reactions With Anaplastic Lymphoma Kinase Tyrosine Kinase Inhibitors. [Extracted from the article]

According to news reporting originating from Shanghai, People's Republic of China, by NewsRx correspondents, research stated, "Dopamine (DA) is one of the most important catecholamine neurotransmitters in the central nervous system. Keywords: Shanghai; People's Republic of China; Asia; Biotechnology; Amino Acids; Aromatic Amino Acids; Biogenic Amines; Catecholamines; Dopamine; Enzymes and Coenzymes; Hydroxylase; Organic Chemicals; Synthase; Tyrosine EN Shanghai People's Republic of China Asia Biotechnology Amino Acids Aromatic Amino Acids Biogenic Amines Catecholamines Dopamine Enzymes and Coenzymes Hydroxylase Organic Chemicals Synthase Tyrosine 761 761 1 06/26/23 20230630 NES 230630 2023 JUN 30 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Current study results on Biotechnology have been published. [Extracted from the article]

Keywords for this news article include: Shanghai, People's Republic of China, Asia, Biology, Life Sciences, Amino Acids, Aromatic Amino Acids, Enzymes and Coenzymes, Synthetase, Tyrosine, University of the Chinese Academy of Sciences. Keywords: Shanghai; People's Republic of China; Asia; Biology; Life Sciences; Amino Acids; Aromatic Amino Acids; Enzymes and Coenzymes; Synthetase; Tyrosine EN Shanghai People's Republic of China Asia Biology Life Sciences Amino Acids Aromatic Amino Acids Enzymes and Coenzymes Synthetase Tyrosine 2371 2371 1 03/23/23 20230324 NES 230324 2023 MAR 24 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Research findings on Life Sciences - Biology are discussed in a new report. [Extracted from the article]