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Objective: Heart disease has been the leading cause of maternal death in developing countries. Although China has made a great effort to reduce maternal mortality ratio, it also has a large inmigrating population, which has made control of maternal mortality a major challenge. This study analyzed major factors of maternal death due to heart disease, and explored the difference of maternal mortality between residents and migrants in Wuhan. Methods: A retrospective study was conducted to analyze 40 cases of maternal death related to heart disease in Wuhan from 2000 to 2016. Results: The ratio of maternal death due to heart disease in Wuhan increased during the seventeenyear period (from 2000 to 2016). In 2016, the constituent ratio of maternal death due to heart disease among all dead of permanent pregnant women rose to 12.50% and the constituent ratio of those among migrant population rose to 40.00%. The top three causes of heart disease-related deaths were congenital heart disease (42.50%), peripartum cardiomyopathy (25.00%), and rheumatic heart disease (17.50%). For those who were migrant population, living in rural area, lower income, less education and poorer prenatal care might have higher risk for the maternal death. Conclusions: Maternal death related to heart disease had been an extrusive problem for pregnant women in Wuhan. Present study indicated improving the health care and management for pregnant women, strengthening the training of medical staff, promoting maternal educational level, and increasing household income were important interventional strategies to reduce the maternal death further. [ABSTRACT FROM AUTHOR]