1. Correlation of Carotid Artery Disease Severity and Vasomotor Response of Cerebral Blood Vessels.
- Author
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Krdžić, Ivana, Čovičković-Šternić, Nadežda, Katsiki, Niki, Isenović, Esma R., and Radak, Đorđe
- Subjects
BLOOD vessels ,CARDIOVASCULAR diseases risk factors ,CAROTID artery diseases ,CEREBRAL circulation ,CHI-squared test ,CONFIDENCE intervals ,HYPERCAPNIA ,RESEARCH funding ,STATISTICS ,T-test (Statistics) ,DATA analysis ,MULTIPLE regression analysis ,PRE-tests & post-tests ,SEVERITY of illness index ,DATA analysis software ,DESCRIPTIVE statistics ,ODDS ratio ,MANN Whitney U Test ,KRUSKAL-Wallis Test ,DISEASE complications - Abstract
We assessed reactivity of cerebral vessels on hypercapnia in patients with carotid occlusive disease. The effects of vascular risk factors on carotid atherosclerosis and vasomotor reactivity (VMR) of cerebral arterioles were also examined. Patients (n = 50) with carotid stenosis (≥30% in 1 or both sides) were included; 30 patients acted as controls. Hypertension, hyperlipidemia, diabetes, cardiac diseases, inflammation, and smoking were recorded. Vasomotor reactivity was assessed with the apnea test by transcranial Doppler ultrasonography and estimated by flow velocity changes in the middle cerebral artery before and after hypercapnia induction. Vasomotor reactivity was defined by the breath holding index, and values under 0.69 were considered critical for VMR impairment. Vasomotor reactivity reduction was significant (P = .004) in patients with severe carotid stenosis (>70%) and with symptomatic carotid disease (P < .05). The risk factors did not significantly influence VMR reduction. Severe carotid stenosis impairs VMR and may increase the risk of stroke, especially in symptomatic patients. [ABSTRACT FROM PUBLISHER]
- Published
- 2015
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