1. Prognostic value of red blood cell distribution width in predicting 3-month functional outcome of patients undergoing thrombolysis treatment for acute ischemic stroke.
- Author
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Kim DY, Hong DY, Kim SY, Park JJ, Kim JW, Park SO, Lee KR, and Baek KJ
- Subjects
- Aged, Aged, 80 and over, Area Under Curve, Female, Humans, Ischemic Stroke epidemiology, Ischemic Stroke mortality, Logistic Models, Male, Middle Aged, Odds Ratio, Outcome Assessment, Health Care methods, Prognosis, ROC Curve, Retrospective Studies, Seoul epidemiology, Statistics, Nonparametric, Thrombolytic Therapy methods, Thrombolytic Therapy statistics & numerical data, Weights and Measures instrumentation, Erythrocytes classification, Ischemic Stroke complications, Outcome Assessment, Health Care statistics & numerical data, Thrombolytic Therapy standards
- Abstract
Abstract: This study was performed to determine whether red blood cell distribution width (RDW) is associated with 3-month poor functional outcome in patients undergoing thrombolytic therapy for acute ischemic stroke.RDW was measured in patients with thrombolytic therapy in emergency department. Functional outcome was assessed after 3 months and poor functional outcome was defined as modified Rankin scale 3 to 6.A total of 240 patients were enrolled, and 82 (34.2%) had a poor functional outcome. The median RDW was significantly elevated in patients with a poor functional outcome compare with those with a good outcome. RDW was independently associated with a 3-month poor functional outcome (odds ratio 3.369, 95% confidence interval 2.214-5.125). The optimal RDW cutoff for predicting 3-month poor functional outcome was 12.8%, and the area under the curve for RDW was 0.818 (95% confidence interval 0.761-0.876). The area under the curve for RDW was higher in male patients than in female patients. The RDW correlated positively with the modified Rankin scale score after 3 months and the initial National Institutes of Health Stroke Scale score.Initial higher RDW level is related to a 3-month poor functional outcome in patients undergoing thrombolytic therapy for acute ischemic stroke., Competing Interests: The authors have no funding and conflicts of interest to disclose., (Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2021
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