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The effects of acute fat feeding on fibrinolytic activity, platelet aggregation, and Stypven time in 10 Africans and 10 Asians are presented and compared with the results previously obtained in 10 Europeans. These indicated that the inhibition of fibrinolytic activity seen in Europeans does not occur in either Africans or Asians although the Stypven time was shortened in all three groups. Platelet aggregation, as measured by the Chandler's tube technique, was inhibited by fat feeding in Europeans but was unchanged in Africans and Asians. The results also indicate that the fibrinolytic activity of Africans and Asians is greater than that of Europeans.