1. The IL12B gene does not confer susceptibility to coeliac disease.
- Author
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Louka AS, Torinsson Naluai A, D'Alfonso S, Ascher H, Coto I, Ek J, Giordano M, Gudjónsdóttir AH, Mellai M, Momigliano-Richiardi P, Percopo S, Samuelsson L, Wahlström J, Greco L, and Sollid LM
- Subjects
- Alleles, Celiac Disease pathology, HLA-DQ Antigens genetics, HLA-DQ alpha-Chains, HLA-DQ beta-Chains, Humans, Interleukin-12 Subunit p40, Intestines pathology, Italy, Polymorphism, Genetic, Scandinavian and Nordic Countries, Celiac Disease genetics, Genetic Predisposition to Disease, Interleukin-12 genetics
- Abstract
Coeliac disease (CD) is a chronic inflammatory disorder where dietary gluten is not tolerated. In the lesion there are gluten reactive T cells predominantly secreting gamma-interferon. Both HLA and non-HLA genes contribute to CD susceptibility. Interleukin-12 (IL-12) regulates gamma-interferon production. The IL12B gene is located in a region (5q31.1-33.1) where there is evidence for linkage with CD. Allele 1 of an IL12B 3'UTR single-nucleotide polymorphism leads to increased expression of IL-12, and was recently implicated in susceptibility for type 1 diabetes (T1D). We found no evidence for association of allele 1 to CD by the transmission/disequilibrium test or case-control approach. No increased frequency was observed in patients belonging to families where the disease was linked to markers on chromosome 5q. Unlike T1D, allele 1 does not appear to confer susceptibility to CD.
- Published
- 2002
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