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Urban regeneration often intends to improve the physical, economic, and social environment of disadvantaged neighborhoods. However, evidence on the consequences of such interventions on place-based social relations is limited in Scandinavia. This study investigates the relationship between urban regeneration and diverse forms of place-based social relations among middle-aged and older social housing residents in Denmark. A longitudinal multi-method design was applied using data from administrative registers and semi-structured individual interviews. The quantitative results showed small changes in household-restricted place-based social relations, whereas participants in the qualitative sample described the disruption of place-based social relations to negatively affect their well-being. • Small changes are observed in household-restricted place-based social relations. • Place-based social relations with neighbors may be disrupted after relocation. • Building operations appear to hinder social interaction among remaining residents. • Demolition may negatively affect participation in organized neighborhood activities. • Urban regeneration seems to negatively affect the well-being of residents. [ABSTRACT FROM AUTHOR]