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Keywords: San Francisco; State:California; United States; North and Central America; Alzheimer Disease; Chromosome Disorders; Congenital Abnormalities; Down Syndrome; Genetic Diseases and Conditions; Genetics; Health and Medicine; Mental Retardation; Nervous System Diseases and Conditions; Neurobehavioral Manifestations; Neurodegenerative Diseases and Conditions; Neurologic Manifestations; Peptides and Proteins; Prions; Proteins EN San Francisco State:California United States North and Central America Alzheimer Disease Chromosome Disorders Congenital Abnormalities Down Syndrome Genetic Diseases and Conditions Genetics Health and Medicine Mental Retardation Nervous System Diseases and Conditions Neurobehavioral Manifestations Neurodegenerative Diseases and Conditions Neurologic Manifestations Peptides and Proteins Prions Proteins 341 341 1 06/12/23 20230616 NES 230616 2023 JUN 16 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Data detailed on Genetic Diseases and Conditions - Down Syndrome have been presented. In brain extracts from 28 deceased donors with DS, ranging in age from 19 to 65 y, we found nearly all DS brains had readily measurable levels of A beta and tau prions. [Extracted from the article]

Applying partial least squares regression to all biochemical and prion infectivity measurements, we demonstrated that the ALS-PDC cohort has a unique molecular signature distinguishable from AD." In ALS-PDC brain samples, we detected high titers of tau and A beta prions, but we did not detect alpha-synuclein prions in either cohort. Findings from University of California San Francisco (UCSF) Provides New Data about Amyotrophic Lateral Sclerosis (Guam Als-pdc Is a Distinct Double-prion Disorder Featuring Both Tau and A?. [Extracted from the article]