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3 results on '"Vardi A."'

1. THE FOUR HORSEMEN OF RUSSIA'S ECONOMIC APOCALYPSE.

Author

VARDI, NATHAN

Subjects
ECONOMICS, PETROLEUM industry, ECONOMIC conditions in Russia, 1991-
Abstract

The article looks at the Russian economy and petroleum industry, focusing on the wealth which four Russian businessmen, Mikhail Fridman, Viktor Vekselberg, Len Blavatnik and German Khan, have garnered during the recent period in which Russia has faced severe economic problems. Topics include their sale of their stake in petroleum company TNK-BP to oil company Rosneft, the economic and foreign policies of Russian President Vladimir Putin, and the sharp drop in the value of the ruble.

Published
2015

2. The Market Is Signaling The End Of Vladimir Putin.

Author

Vardi, Nathan

Subjects
FINANCIAL markets, STOCKS (Finance), CAPITAL movements, INVESTORS
Abstract

The author contends that financial markets are not responding positively to the re-election of Vladimir Putin as the president of Russia in March 2012. He mentions the decline of the Russian Trading System Index of Russian stocks since Putin's re-election in addition to the devaluation of the ruble by 15 percent against the U.S. dollars. The amount of capital outflow and investors departure from Russia during the first four months of 2012 are also addressed.

Published
2012

3. Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases.

Author

Oftedal BE, Hellesen A, Erichsen MM, Bratland E, Vardi A, Perheentupa J, Kemp EH, Fiskerstrand T, Viken MK, Weetman AP, Fleishman SJ, Banka S, Newman WG, Sewell WA, Sozaeva LS, Zayats T, Haugarvoll K, Orlova EM, Haavik J, Johansson S, Knappskog PM, Løvås K, Wolff AS, Abramson J, and Husebye ES

Subjects
Adolescent, Adult, Amino Acid Sequence, Autoimmunity genetics, Child, Child, Preschool, Female, Gene Frequency, Humans, Male, Microsatellite Repeats genetics, Molecular Sequence Data, Norway, Organ Specificity genetics, Pedigree, Penetrance, Phenotype, Russia, Young Adult, AIRE Protein, DNA Mutational Analysis methods, Genes, Dominant genetics, Mutation genetics, Polyendocrinopathies, Autoimmune genetics, Transcription Factors genetics
Abstract

The autoimmune regulator (AIRE) gene is crucial for establishing central immunological tolerance and preventing autoimmunity. Mutations in AIRE cause a rare autosomal-recessive disease, autoimmune polyendocrine syndrome type 1 (APS-1), distinguished by multi-organ autoimmunity. We have identified multiple cases and families with mono-allelic mutations in the first plant homeodomain (PHD1) zinc finger of AIRE that followed dominant inheritance, typically characterized by later onset, milder phenotypes, and reduced penetrance compared to classical APS-1. These missense PHD1 mutations suppressed gene expression driven by wild-type AIRE in a dominant-negative manner, unlike CARD or truncated AIRE mutants that lacked such dominant capacity. Exome array analysis revealed that the PHD1 dominant mutants were found with relatively high frequency (>0.0008) in mixed populations. Our results provide insight into the molecular action of AIRE and demonstrate that disease-causing mutations in the AIRE locus are more common than previously appreciated and cause more variable autoimmune phenotypes., (Copyright © 2015 Elsevier Inc. All rights reserved.)

Published
2015
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