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Objectives To access the nutritional status of cystic fibrosis patients in Russia in the perspective of preventive measures’ development. Methods Nutritional status was evaluated for 1026 patients with CF from 16 regions and the city of Novosibirsk. Nutritional status of CF patients was identified with the help of body mass index (BMI) by Quetelet [weight (kg)/height (m 2 )]. Calculation of BMI percentile was performed with assistance of the World Health Organization's program: WHO Anthro and Anthro plus. Results BMI's percentile's median accounted for 28.0 (57.6) for boys and 24.0 (49.0) for girls in the group of children from 2 to 17 years old. BMI was recorded at the level of more than 50 percentile for girls under 3 years old and for boys under the age of 5. Decrease of BMI was observed during the period from 6 to 10 years (start of schooling). Significant decrease of BMI is registered from the beginning of puberty (around 11 years old). With regard to adults, BMI's median was 18.5 kg/m 2 (4.0 kg/m 2 ) for males and 18.9 kg/m 2 (3.7 kg/m 2 ) for females. The dependence of respiratory function (FEV1) from nutritional status was determined. Survey has shown that out of 68 families with CF patients only 10% of children and teenagers receive special mixtures for enteral nutrition with 5% on a regular basis. Conclusion Thus, it is recommended to start prevention of nutritional deficiency at the age of 4 for boys and at the age of 2 for girls. It is necessary to take preventive measures for all children before entering puberty. Doctors and patients should be better informed about possibility of enteral feeding. [ABSTRACT FROM AUTHOR]