1. Coagulopathy in Acute Puumala Hantavirus Infection.
- Author
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Koskela S, Mäkelä S, Strandin T, Vaheri A, Outinen T, Joutsi-Korhonen L, Pörsti I, Mustonen J, and Laine O
- Subjects
- Acute Disease, Acute Kidney Injury virology, Disseminated Intravascular Coagulation virology, Europe epidemiology, Hemorrhagic Fever with Renal Syndrome epidemiology, Hemorrhagic Fever with Renal Syndrome virology, Russia epidemiology, Thrombosis virology, Blood Coagulation Disorders virology, Hemorrhagic Fever with Renal Syndrome complications, Hemorrhagic Fever with Renal Syndrome physiopathology, Puumala virus pathogenicity
- Abstract
Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein-kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and thrombosis.
- Published
- 2021
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