1. Plasmid-Mediated mcr-1 Colistin Resistance in Escherichia coli from a Black Kite in Russia.
- Author
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Tarabai H, Valcek A, Jamborova I, Vazhov SV, Karyakin IV, Raab R, Literak I, and Dolejska M
- Subjects
- Animal Migration, Animals, Anti-Bacterial Agents metabolism, Anti-Bacterial Agents pharmacology, Colistin metabolism, Colistin pharmacology, Escherichia coli drug effects, Escherichia coli enzymology, Escherichia coli isolation & purification, Escherichia coli Infections epidemiology, Escherichia coli Infections microbiology, Escherichia coli Infections transmission, Microbial Sensitivity Tests, Plasmids chemistry, Plasmids metabolism, Russia epidemiology, Whole Genome Sequencing, Drug Resistance, Bacterial genetics, Escherichia coli genetics, Escherichia coli Infections veterinary, Escherichia coli Proteins genetics, Raptors microbiology
- Abstract
The gene mcr-1 conferring resistance to last-line antibiotic colistin has been reported globally. Here, we describe the first detection of plasmid-mediated colistin resistance in Russian wildlife, an isolate of Escherichia coli sequence type 2280 from a black kite ( Milvus migrans ) scavenging raptor. Whole-genome sequencing and plasmid transferability experiments revealed that mcr-1.1 was located on conjugative IncI2 plasmid pDR164 (59891 bp). Migratory black kites may contribute to the global spread of mobile colistin resistance., (Copyright © 2019 American Society for Microbiology.)
- Published
- 2019
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