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Recent evidence underscores the importance of greenspace exposure in promoting physical activity, and in having a positive impact on mental health and cognitive development. Accessibility has been identified to be the primary motivating factor when it comes to encouraging greenspace use and, correspondingly, exposure. Existing quantitative approaches to measuring greenspace accessibility predominantly focus on the areas surrounding home locations, often disregarding access from other settings such as schools or workplaces, exposures while on the move, and mobility differences among different population age groups. This article introduces a novel method to measure greenspace accessibility that considers access from different activity settings (i.e., homes, schools, and the commutes between them) for children and adolescents, while accounting for the dependency of human access on the road network. We use Amsterdam, Rotterdam, and The Hague in the Netherlands as case studies to illustrate the utility of our method. Compared to conventional measures of greenspace accessibility, we show that accounting for school and commuting settings, in addition to residences, captures previously untapped accessibility aspects for both children and adolescents. Our approach can be replicated in other cities worldwide, with the aspiration to provide planners and public health policy-makers with a methodological tool that can help in evaluating access and use of greenspaces when designing health-promoting interventions. • Accessibility is a key enabling factor for the use of and exposure to greenspaces. • Existing measures often disregard differences in activity settings and age groups. • Greenspace accessibility varies when measured from home, school, and while commuting. • Configuration and density of facilities surrounding greenspaces affect accessibility. [ABSTRACT FROM AUTHOR]