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Introduction: Scientific literature has repeatedly highlighted the mutual influence between the somatic and visceral systems of the human body, which finds its maximum expression in the genesis of Myofascial Key Trigger Points (MKTrPs). It has been observed that the rebalancing of somato-visceral and viscero-somatic reflexes can occur through peripheral stimulations of these MKTrPs using different techniques. Aim: Our study wants to demonstrate the effectiveness of the treatment of MKTrPs through Focused Mechano-Acoustic Vibrations (FMAV) administered through the Vibration Sound System (Vissman Srl, Fiano Romano, Italy) in cardiac and cancer surviving patients affected by Chronic Low-Back Pain (CLBP). Material and methods: Clinical data of 20 subjects, examined and treated at the Ce.Fi.R.R. Rehabilitation Center located in the Gemelli Molise Hospital (Campobasso, Italy) and affected by CLBP, were collected and observed from January to June 2023. The sample was composed by 12 women and 8 males, average age 48 years old. The patients underwent FMAV treatment for a total of 8 biweekly sessions. The evaluation systems considered for pain were the VAS Score and for the pain assessment and the Biometric Postural Index (BPI) (normal value 0-10) derived from the Postural Digitalized Biometry (Diasu Health Technologies, Rome, Italy). The treatment consisted in the application of FMAV for 2 minutes on each of the 4 most dysfunctional MKTrPs previously identified through the study of dermatomal skin impedance thanks to an impedence-metric device named EnF (Fast Therapies, Carpenedolo, Italy). Results: A statistically significant reduction was detected both for the BPI (T0=13.6, T1=11.2, p=0.004) and the VAS scale (T0=6,45, T1=4,75, p<0.001). Conclusions: The study showed improvements in terms of pain and posture in patients suffering from CLBP, consequently reflecting on their quality of life without side effects, through a targeted treatment producing systemic neurophysiological effects, according to the principle of minimum stimulus and greater response. [ABSTRACT FROM AUTHOR]