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Objective: Treatment of stress urinary incontinence consists of a wide range of options, from conservative therapies like lifestyle changes, medication, pelvic floor muscles exercises, electro-stimulation, to minimally invasive procedures- injection of collagen, suburethral slings TVT / TOT and last but not least, invasive surgical treatment reserved for recurrent and complex cases. Among the latest minimally invasive procedures reported in literature, the injection of intra-and perisphincterian of autologous stem cell (mioblasts and /or mature fibroblasts grown and multiplied in the laboratory from biopsy samples taken from the pectoralis muscles). Material and method: On October 18, 2010, in "Fundeni" Clinical Institute of Uronephrology and Renal Transplantation was performed the first stem cell implantation procedure in the urethral sphincter, in Romania. Results: Assessment at 6 weeks, the quality of life questionnaires, micturition diary and clinical examination revealed a stunning decrease of urine loss from 6 pads / day at one per day, which significantly improved the patient's quality of life. Conclusions: Stem-cell- mioblasts therapy may represent in the future an every-day intervention in the urologist's armamentarium. The effectiveness of this treatment can change the course of therapy and last but not least, the accessibility to urological evaluation of patients with stress urinary incontinence. Clinical and urodynamic evaluations will continue and will be future scientific topics. [ABSTRACT FROM AUTHOR]

Introduction. We performed an univariate analysis in order to identify prognostic factors for long term cancer specific survival. Materials and methods. Patients were enrolled between December 2005 - July 2007, at Fundeni Urological Surgery Clinic in Bucharest. Patients were followed prospectively, the clinical data was stored on electronic records. Kaplan Meier survival plots and log rank test revealed prognostic factors involved in five year cancer specific survival. Results. Median follow-up of patients (N = 293) was of 54.2 months. Perioperative mortality was 1.7%. There were 101 deaths including 59 disease related (58.4%). Correlational analysis highlighted significant recorded variables; log rank analysis showed statistically significant differences for the T, N, M staging system, histologic type, Fuhrman grade, sarcomatoid differentiation, tumor size and age. In our study cancer specific survival was 92.8% for pT1 (N = 48), pT2 83.3% (N = 3), pT3 68.2% (N = 145), zero for pT4 (n = 4) (p <0.0001, Χ2 = 144). We could not find any difference in survival for T1a and T1b stages (TNM 2002): T1a (n = 46) 92.4%, T1b (n = 14) 92.9%. Lymph nodes involvment and presence of distant metastasis at diagnosis revealed a dramatic decrease in five year cancer specific survival (20% for M1, 44% for PN1 (N = 17), 13.9% for PN2 (N = 12) (c2 = 107). The study showed statistically significant differences for specific survival at five years between clear cell variant, 71% (N = 200), papillary 62.5% (N = 16), cromophobe 100% (N = 20), unclassifiable 50% (N = 5), another 55%. (p = 0.006 log rank test). Fuhrman grade was proved to be a major prognostic factor, cause specific survival being 78.3% (N = 54), 75.1% (N = 122) 39.7% (N = 23) zero for G4 (N = 1). (p <0.0001) Conclusions. Our study validates TNM elements, histological type, Fuhrman grade, sarcomatoid differentiation, tumor size and age at diagnosis as prognostic factors in renal cancer. The values for five years cause specific survival obtained in our study confirms european therapeutic attitude in our Department. [ABSTRACT FROM AUTHOR]

Rationale: Stress urinary incontinence is still a "battlefield" for many minimally invasive therapies, but, unfortunately, few can restore the anatomical and functional background of this disorder., Objective: Assessing the latest minimally invasive procedures of intra and perisphincterian injection of autologous stem cells., Method and Result: The first stem cell implantation (myoblasts and /or mature fibroblasts grown and multiplied in the laboratory from biopsy samples taken from the pectoralis muscle) in the urethral sphincter was performed on October 18, 2010, in "Fundeni" Clinic of Urology and Renal Transplantation, in Romania., Discussion: The follow-up at six weeks with the quality of life questionnaires, micturition diary and clinical examination revealed a decrease of urine loss from six pads/ day at one per day, which significantly improved the patient's quality of life according to visual analogue scale. Clinical and urodynamic evaluations will continue and will be future scientific topics.