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2. NGS combined with phylogenetic analysis to detect HIV-1 dual infection in Romanian people who inject drugs.

Author

Popescu B, Banica L, Nicolae I, Radu E, Niculescu I, Abagiu A, Otelea D, and Paraschiv S

Subjects
Genetic Variation, Genome, Viral genetics, Genotype, HIV Infections blood, HIV-1 classification, HIV-1 isolation & purification, High-Throughput Nucleotide Sequencing, Humans, Phylogeny, RNA, Viral genetics, Reassortant Viruses classification, Reassortant Viruses genetics, Reassortant Viruses isolation & purification, Romania, Sequence Analysis, DNA, Substance Abuse, Intravenous virology, Superinfection blood, env Gene Products, Human Immunodeficiency Virus genetics, Drug Users, HIV Infections complications, HIV Infections virology, HIV-1 genetics, Superinfection virology
Abstract

Dual HIV infections are possible and likely in people who inject drugs (PWID). Thirty-eight newly diagnosed patients, 19 PWID and 19 heterosexually HIV infected were analyzed. V2V3 loop of HIV-1 env gene was sequenced on the NGS platform 454 GSJunior (Roche). HIV-1 dual/multiple infections were identified in five PWID. For three of these patients, the reconstructed variants belonged to pure F1 subtype and CRF14_BG strains according to phylogenetic analysis. New recombinant forms between these parental strains were identified in two PWID samples. NGS data can provide, with the help of phylogenetic analysis, important insights about the intra-host sub-population structure., (Copyright © 2018 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.)

Published
2018
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