Abstract: Background: Large population-based studies link inflammation to the prospective development of cardiovascular events. We investigated the time-dependent associations between variations in infectious disease as reflected by alterations of C-reactive protein (CRP)-levels in the general population and the number of cardiovascular events and death rates. Methods: Retrospectively, we studied CRP- and Troponin T (TNT) values drawn for any clinical reason, the number of cardiovascular events and the death rates in the population of Southern Rogaland, Norway over a 2 year period. Results: The mean and the sum of CRP values per week were significantly correlated with the number of patients with a TNT≥0.03 µg/l in the same week (R =0.42, R =0.43, respectively, p <0.001 for both analysis). Further, we found a significant correlation between the mean and the sum of CRP values per week and the number of patients admitted with a cardiovascular event 2 weeks later (R =0.20, R =0.26; p =0.047, p =0.009, respectively). The sum of CRP values per week was significantly correlated to the death rates in the following week (R =0.30, p =0.002). Conclusions: These findings further support the hypothesis that inflammation assessed by CRP levels is linked to the prospective development of cardiovascular events and all cause mortality. [Copyright &y& Elsevier]