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Multidrug-resistant bacteremia 15 G-ve and 1 G+ve isolates were collected from inpatients and outpatients departments at Security Forces Hospital in Riyadh, Saudi Arabia. In studying the multidrug-resistance to antibiotics, it was recorded that the G-ve isolates of E. coli (11093623) & (11161644) were resistance to 19 out of 20 tested antibiotics except antibiotic(CN), while the G+ve isolate of MRSA was resistance to 9 out of 18 antibiotics, and it was sensitive to antibiotic (OX and CZ). The Gold Nanoparticles (AuNPs) was examined to discourage the growth of the multidrug-resistance isolates. Rod-AuNPs were the best to discourage the growth of tested bacteria, followed by the Spherical-AuNPs. Swabs were taken from inhibition zone resulting from the inhibitory effect of AuNPs, towards the tested bacteria and re-inoculated on the Nutrient Agar medium, to determine either the bacteriostatic/bactericidal effect for different NPs. The study proved that Rod-AuNPs gave bacteriostatic effect on Pseudomonas aeruginosa (11093627) & (11132667), Enterobacter cloacae (11159053) and Citrobacter freundii(11176991)&(11182565), and gave a bactericidal effect to the rest of the tested isolates. The Spherical-AuNPs gave a bacteriostatic impact of all tested isolates. Electromicroscopic studies disclosed the effect of AuNPs, either rods or spherical-shaped, on the external shape of some of the pathogenic tested bacteria e.g. E. coli, Klebsiella pneumoniae and P. aeruginosa of G-ve bacteria, MRSA of G+ve bacteria. From results obtained, it can be concluded that the nanostructures and morphologies of AuNPs may offer new possibilities for promising therapeutic applications of multidrug-resistance bacteremia. [ABSTRACT FROM AUTHOR]