1. Phenylpropanoid-Conjugated Triterpenoids from the Leaves of Actinidia arguta and Their Inhibitory Activity on α-Glucosidase.
- Author
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Ahn JH, Park Y, Yeon SW, Jo YH, Han YK, Turk A, Ryu SH, Hwang BY, Lee KY, and Lee MK
- Subjects
- Enzyme Inhibitors pharmacology, Magnetic Resonance Spectroscopy, Mass Spectrometry, Molecular Docking Simulation, Molecular Structure, Plant Extracts chemistry, Plant Extracts pharmacology, Republic of Korea, Actinidia chemistry, Plant Leaves chemistry, Triterpenes chemistry, Triterpenes pharmacology, alpha-Glucosidases drug effects
- Abstract
Actinidia arguta , commonly called hardy kiwifruit or kiwiberry, has cold-resistant properties and can be cultivated in Asia, including Korea. Seven new triterpenoids ( 2 - 4 and 8 - 11 ) along with eight known triterpenoids were isolated from the leaves of A. arguta through various chromatographic techniques. The new triterpenoids were defined as actiniargupenes A-C ( 2 - 4 ), actinidic acid derivatives with phenylpropanoid constituent units, dehydroisoactinidic acid ( 8 ), and actiniargupenes D-F ( 9 - 11 ), asiatic acid derivatives with phenylpropanoid substituents, on the basis of 1D and 2D NMR and MS data. Among the triterpenoids, those with a phenylpropanoid constituent unit showed inhibitory activity on α-glucosidase, which suggested the importance of the phenylpropanoid moiety. Molecular docking analysis demonstrated the interaction between the 4'-OH group of the phenylpropanoid moiety and α-glucosidase.
- Published
- 2020
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