1. The therapeutic effects on U87 and SAS cells using Proton Linac based Boron Neutron Capture Therapy in Korea.
- Author
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Seo IH, Seo HJ, Na D, Yoo M, Schwint A, Kim SH, Lee J, Jeon SJ, Choi JW, Kim WH, Park K, Yee GT, and Kim WK
- Subjects
- Humans, Protons, Neutrons, Boron Compounds therapeutic use, Republic of Korea, Brain Neoplasms metabolism, Boron Neutron Capture Therapy methods
- Abstract
A proton linac based boron neutron capture therapy system (A-BNCT, 10MeV, 4mA) was successfully developed in Korea. We performed in vitro experiments with U87 and SAS cells and revealed the efficacy of a binary therapy BNCT using epithermal neutrons and boronophenylalanine (BPA). The results revealed that BNCT showed cancer cell selectivity and caused cell death. Further in vitro studies can be a valuable method to characterize an A-BNCT system. We expect BNCT to become a treatment option for cancer patients., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier Ltd.)
- Published
- 2023
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