1. Age related non-type 2 inflammation and its association with treatment outcome in patients with chronic rhinosinusitis with nasal polyp in Korea.
- Author
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Kim JW, Won TB, Woo H, Yang SK, Phannikul C, Ko SA, Kim H, Rhee CS, and Cho SW
- Subjects
- Adult, Age Factors, Chronic Disease, Cross-Sectional Studies, Eosinophilia diagnosis, Eosinophilia immunology, Eosinophilia metabolism, Female, Humans, Inflammation Mediators metabolism, Interleukin-5 metabolism, Leukocyte Count, Male, Middle Aged, Nasal Polyps diagnosis, Nasal Polyps immunology, Nasal Polyps metabolism, Republic of Korea, Retrospective Studies, Rhinitis diagnosis, Rhinitis immunology, Rhinitis metabolism, Sinusitis diagnosis, Sinusitis immunology, Sinusitis metabolism, Time Factors, Treatment Outcome, alpha 1-Antitrypsin metabolism, Eosinophilia surgery, Nasal Polyps surgery, Rhinitis surgery, Sinusitis surgery
- Abstract
This study aimed to investigate the effect of age in patients with chronic rhinosinusitis with nasal polyp (CRSwNP). 269 patients were divided into eosinophilic and non-eosinophilic groups based on tissue eosinophilia, defined by eosinophils accounting for more than 20% of the total inflammatory cells. Patients were then further divided into younger and older groups based on the age of 35 years. Clinical characteristics including blood eosinophil, Lund Mackay score, and modified Lund-Kennedy (mLK) scores were compared. Levels of 14 cytokines from nasal tissues of an additional 78 patients were analyzed. Tissue eosinophilia was significantly associated with age and the proportion of non-eosinophilic CRSwNP was significantly higher in younger patients as compared to older patients (79.2% vs 56.6%). There was no difference in clinical characteristics and cytokine levels between the younger and older patients with eosinophilic CRSwNP. In contrast, in patients with non-eosinophilic CRSwNP, younger patients had significantly lower preoperative blood eosinophils and higher mLK scores at three and six months, postoperatively, compared to older patients. Alpha-1 antitrypsin and IL-5 levels were significantly lower in younger patients than in older patients in non-eosinophilic CRSwNP. This study suggests a potential association between age, non-type 2 inflammation and treatment outcome in CRSwNP., (© 2022. The Author(s).)
- Published
- 2022
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