1. Protective effect of traditional Korean fermented soybean foods ( doenjang ) on a dextran sulfate sodium-induced colitis mouse model.
- Author
-
Yang HJ, Jeong SJ, Ryu MS, Ha G, Jeong DY, Park YM, Lee HY, and Bae JS
- Subjects
- Animals, Anti-Inflammatory Agents pharmacology, Colon metabolism, Dextran Sulfate adverse effects, Disease Models, Animal, Interleukin-6 genetics, Interleukin-6 metabolism, Mice, Nitric Oxide metabolism, Republic of Korea, Signal Transduction, Glycine max metabolism, Tumor Necrosis Factor-alpha metabolism, Colitis chemically induced, Colitis drug therapy, Colitis metabolism, Colitis, Ulcerative chemically induced, Colitis, Ulcerative drug therapy, Colitis, Ulcerative pathology, Fermented Foods
- Abstract
Objective : The cause of ulcerative colitis (UC) is unknown, and the use of anti-inflammatory and immunosuppressive drugs with certain side effects is currently replacing treatment. Therefore, it is important to find new healthy foods or ingredients that exhibit potential protective and anti-inflammatory effects on UC. This study investigated the potential protective effect of doenjang on dextran sulfate sodium (DSS)-induced colitis in a mouse model. Materials and methods : Four doenjang samples (TCD21-51-1, TCD21-55-1, TMD21-16-1, and TFD21-1-1) were used. To examine the effects of the four doenjang samples on UC caused by DSS in a mouse model, the clinical symptoms of UC, such as body weight, disease activity index (DAI), and colon macroscopic damage index (CMDI) were analyzed. Moreover, immune-related blood cell counts, serum levels and protein expression of tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6), and nitric oxide (NO) production were measured in DSS-induced UC in mice for analysis. Results : The four doenjang samples increased the colon length shortened by DSS, reduced DAI (diarrhea and hemoccult), CMDI (ulceration, inflammation, and hemorrhage) and the content of immune-related cells in the blood. Moreover, the levels of TNF-α, IL-6, and NO increased by DSS were decreased by doenjang , and tissue damage was significantly reduced. Conclusions : These findings confirmed that doenjang exerts protective effects against UC, suggesting its possible use in developing therapeutic strategies or functional products.
- Published
- 2022
- Full Text
- View/download PDF