1. Effect of Memantine on QT/QTc Interval in a Healthy Korean Population.
- Author
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Park JW, Kim KA, and Park JY
- Subjects
- Administration, Oral, Adult, Drug Administration Schedule, Electrocardiography methods, Excitatory Amino Acid Antagonists administration & dosage, Excitatory Amino Acid Antagonists adverse effects, Excitatory Amino Acid Antagonists blood, Follow-Up Studies, Healthy Volunteers, Heart Rate physiology, Humans, Long QT Syndrome blood, Long QT Syndrome chemically induced, Male, Memantine adverse effects, Middle Aged, Republic of Korea epidemiology, Young Adult, Electrocardiography drug effects, Heart Rate drug effects, Memantine administration & dosage, Memantine blood, Population Surveillance methods
- Abstract
Studies on the effects of memantine on QT prolongation have yielded conflicting results. For a long time, memantine was reported to be a safe drug without QT prolongation; however, several case studies have reported memantine-induced QT prolongation in Alzheimer's patients. This study evaluated the relationship between memantine blood levels, and QT interval changes. Over a 2-week period, we orally administered 20 mg of memantine daily to achieve a steady state in 57 healthy Korean subjects. We measured and analyzed the QT interval and blood memantine concentrations simultaneously before and after treatment, as well as 2 weeks after the last dosing. Correlation analysis was done between blood memantine level and QT interval. No serious adverse events occurred during the study period. Repeated dosing of memantine did not show clinically significant QT interval changes after treatment. Regression analysis was performed based on the results; there was no statistical association between memantine blood level and QT prolongation. In conclusion, the results of the present study demonstrated no clinically significant changes in the QT interval with therapeutic blood levels of memantine., (© 2021, The American College of Clinical Pharmacology.)
- Published
- 2021
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