1. Prognostic factors for long-term poor outcomes after acute ischemic stroke in very old age (>80 years) patients: Total cholesterol level might differently influence long-term outcomes after acute ischemic stroke at ages above 80 years.
- Author
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Cha JK, Lim JH, Kim DH, Nah HW, Park HS, Choi JH, Suh HK, and Huh JT
- Subjects
- Age Factors, Aged, Aged, 80 and over, Brain Ischemia blood, Brain Ischemia therapy, Databases, Factual, Female, Humans, Male, Multivariate Analysis, Prognosis, Republic of Korea, Retrospective Studies, Risk Assessment, Severity of Illness Index, Sex Factors, Statistics, Nonparametric, Stroke blood, Stroke therapy, Survival Analysis, Time Factors, Brain Ischemia mortality, Cause of Death, Cholesterol blood, Frail Elderly statistics & numerical data, Stroke mortality
- Abstract
Aim: We investigated the differences in determinant factors for functional outcomes between patients aged >80 years and those aged <80 years after acute ischemic stroke (AIS). In particular, we would like to know the differential impacts of initial total cholesterol (TC) levels between the two groups., Methods: We defined a poor outcome as 3-6 modified Rankin Scale 90 days after AIS., Results: In the present study, 2772 participants were enrolled. Among them, 374 patients (13.5%) were aged >80 years, and 1061 patients had a poor outcome 90 days after AIS. The proportion was significantly higher in patients aged >80 years than in those aged <80 years after AIS. Regarding factors relating to poor outcomes, previous history of stroke, stroke severity and stroke subtypes of ischemic stroke were independent factors in patients aged <80 years, and the stroke severity and initial TC level independently influenced the outcome for patients aged >80 years. In particular, risk of poor outcome adjusted for age, stroke severity and subtypes of ischemic stroke for patients (OR [95% CI]) in the first quartile range (≤157 mg%) were 2.21 (1.06-4.62), in the third quartile range (184-210 mg%) 2.76 (1.27-6.01) and in the fourth quartile range (≥211 mg%) 2.75 (1.21-6.24) compared with those in the second quartile range (158-183 mg%) in patients aged >80 years., Conclusions: There were also some differences in related factors regarding occurrences of poor outcome between the two groups. In particular, the initial TC level might play a crucial role for the outcome after AIS in the very old population., (© 2014 Japan Geriatrics Society.)
- Published
- 2015
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