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Abstract: Objective: To report a comparative clinical and histopathological study on oliguric and non-oliguric acute renal failure (ARF) in malaria. Method: 311 consecutive cases of malaria out of which 74 (23.79%) had ARF as per WHO criteria were conducted. Mean age was 32.58 (range 15–60 years) and male: female was 2:1. Result: Most of the cases developed ARF within 10 d of onset. 18 cases (11 falciparum, 2 mixed, 5 vivax) presented with oliguric and 56 (41 falciparum, 6 mixed, 9 vivax) with non-oliguric renal failure. Associated major manifestations were jaundice (75.68%), cerebral malaria (41.89%), bleeding manifestations (32.43%), severe anemia (27.03%), hypotension (25.68%), multi-organ failure (18.92%), severe thrombocytopenia (12.16%), and ARDS (8.11%). Kidney biopsy (n=20) showed acute tubular necrosis (n=7), Mesangioproliferative glomerulonephritis (n=4) or both (n=9). Hemodialysis was done in 8 cases of oliguric renal failure out of which 4 survived (average no. of session 2.9). Conclusion: Most of the cases recovered within 3 weeks. Total mortality was 28.38% (n=21) and mortality was more in oliguric renal failure (72.22%) as compare to non-oliguric renal failure (14.29%). [Copyright &y& Elsevier]

Concentrated brines and bitterns rejected from various processes contain mineral salts of economic value. For example, sulphate-rich bittern generated at saltworks in the Rajasthan state of India exceeds 3 million tons annually and requires adequate treatment. Resource recovery from such unutilized by-products presents a sustainable waste management approach. This work presents the development and evaluation of a process for sodium-sulphate (Na 2 SO 4) recovery from sulphate-rich bitterns using an integrated process combining cooling crystallization, filtration, and drying as major unit operations. A parametric study has been conducted to investigate the effect of various operating parameters on product (anhydrous sodium-sulphate) yield and quality. Chemical analysis, TGA, P-XRD, and SEM-EDX techniques were used to characterize the product quality and purity. Based on the parametric studies, a sodium-sulphate production process was designed, and material & energy balance was established. The mass balance calculations have shown that 1 ton of anhydrous Na 2 SO 4 (~97 wt% purity) can be produced from 6.31 tons of bittern having a sulphate ion concentration of about 140.8 ± 6.94 g/l. Subsequently, the economic feasibility of a 5 ton/day anhydrous Na 2 SO 4 capacity plant has been evaluated using the cost and profitability analysis. The engineering-economic calculations suggest that the sodium-sulphate production from bittern can be economically favourable, achieving a payback period of 3.5 years. The optimized parameters and economics presented in this paper could significantly help implement an actual sodium-sulphate recovery unit using sulphate-rich bittern as feed. [Display omitted] • Techno-economic feasibility of sodium-sulphate production from bittern is evaluated. • The effect of different parameters on product yield and quality has been investigated. • One ton of anhydrous sodium-sulphate (97% purity) can be produced from six tons of bittern. • Sodium-sulphate recovery from sulphate-rich bittern can be economically favourable at higher plant capacity. [ABSTRACT FROM AUTHOR]