1. 5' flanking variants of resistin are associated with obesity.
- Author
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Engert, James C., Vohl, Marie-Claude, Williams, Scott M., Lepage, Pierre, Loredo-Osti, J C., Faith, Janet, Doré, Carole, Renaud, Yannick, Burtt, Noë P., Villeneuve, Amélie, Hirschhorn, Joel N., Altshuler, David, Groop, Leif C., Després, Jean-Pierre, Gaudet, Daniel, Hudson, Thomas J., Doré, Carole, Burtt, Noël P, Villeneuve, Amélie, and Després, Jean-Pierre
- Subjects
GENETIC polymorphisms ,DIABETES ,OBESITY - Abstract
Diabetes and obesity have long been known to be related. The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice. A search for sequence variants at the human resistin locus identified nine single-nucleotide polymorphisms (SNPs) but no coding variants. An investigation into the association of these SNPs with diabetes and obesity revealed two 5' flanking variants (g.-537 and g.-420), in strong linkage disequilibrium, that are associated with BMI. In nondiabetic individuals from the Quebec City area and the Saguenay-Lac-St-Jean region of Quebec, the g.-537 mutation (allelic frequency = 0.04) was significantly associated with an increase in BMI (P = 0.03 and P = 0.01, respectively). When the data from these two populations were combined and adjusted for age and sex, both the g.-537 (odds ratio [OR] 2.72, 95% CI 1.28-5.81) and the g.-420 variants (1.58, 1.06-2.35) were associated with an increased risk for a BMI > or =30 kg/m(2). In contrast, in case/control and family-based study populations from Scandinavia, we saw no effect on BMI with either of these promoter variants. No association was seen with diabetes in any of the population samples. [ABSTRACT FROM AUTHOR]
- Published
- 2002
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