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In this paper, we present zircon U-Pb age and Hf isotope data to document the significance of magma mixing in the formation of Late Jurassic granitoid intrusions in the eastern Qinling Orogen, China. The Muhuguan granitoid pluton from this orogen consists of monzogranite and lesser biotite granite and granodiorite, all containing abundant hornblende-rich cumulates, dioritic xenoliths, and mafic magmatic enclaves (MMEs). The monzogranite and granodiorite are intruded by a number of lamprophyre dykes. Both a cumulate and a dioritic xenolith samples have concordant zircon U-Pb ages of ca. 161 ± 1 Ma, but possess contrasting Hf isotopic compositions. The cumulate has more radiogenic zircon Hf isotopes with negative ε( t) values (−7.9 to −2.5) and T ages of 0.9-1.1 Ga, indicating its derivation likely from basaltic rocks of the Neoproterozoic to early Paleozoic Kuanping Group in the area. The dioritic xenolith has much lower zircon ε( t) values of −19.5 to −8.8 and T ages of 2.4-1.7 Ga, consistent with a juvenile Paleoproterozoic crust source presumably represented by the metabasic rocks of the Qinling Group in the area. Individual samples of the monzogranite, MME, and a lamprophyre dyke have U-Pb ages of 150 ± 1, 152 ± 1, and 152 ± 1 Ma, respectively, demonstrating coeval mafic and felsic magmatism in the Late Jurassic. The lamprophyre dyke has homogeneous, highly negative zircon ε( t) values (−29.8 to −24.8) and Archean T ages (3.0-2.7 Ga), and its genesis is interpreted as partial melting of an ancient enriched subcontinental mantle source. Zircons from the fine-grained MME show a large range of ε( t) between −29.1 and −9.8, overlapping values of the monzogranite and lamprophyre dyke samples. Zircon U-Pb age and Hf isotopes of the MMEs are consistent with their formation by mixing of crustal- and enriched mantle-derived magmas. The main group of zircons from the monzogranite has ε( t) values (−17.9 to −9.3) and T ages (2.3-1.8 Ga) that are compatible with the dioritic xenoliths, indicating that the former was produced by partial melting of Paleoproterozoic crustal source with involvement of mantle-derived magmas. Mafic magmatism revealed from the Muhuguan pluton indicates that the eastern Qinling Orogen was dominated by lithospheric extension during the Late Jurassic. Compilation of existing geological and geochronological data suggests that this extensional event started in Late Jurassic (ca. 160 Ma) and persisted into the Early Cretaceous until ca. 110 Ma. The Jura-Cretaceous extension may have resulted from the late Mesozoic westward subduction of the Pacific plate beneath the East Asian continental margin. [ABSTRACT FROM AUTHOR]