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Background: B.serrata is commonly known as Indian olibanum, it is mainly used in the production of Indian frankincense. B.serrata is used for many other purposes including asthma diabetes. The medicinal plant Boswelliaserrata has great potential for treating cancer. Since many cancer therapies have their origins in natural ingredients, this study aims to explore the anti-tumorigenic effect of B.serrata using KB cell line. Materials and methods: Seed of B.serrata was collected and extraction was done. Then the extract was added to the culture and the oral cancer cells were obtained from Pune. The cultured oral cells were incubated in a CO2 incubator. Treated oral cancer cell sample was done MTT assay and gene expression analysis. Result: The collected data from MTT assay and gene expression analysis tabulated using SPSS software. MTT assay results showed gradual decrease in cell viability with increase in concentration of Boswelliaserrata and the gene expression showed up regulation of caspase 3 and 9 expression. Conclusion: From the study, Boswelliaserrata has a significant effect on anti-tumorigenic activity; this might be due to the active bio components present in Boswelliaserrata extract. [ABSTRACT FROM AUTHOR]

Background: Skin cancer caused by exposure to ultraviolet light. As soon as, the DNA is altered, it cannot properly control skin cell growth, leading to cancer. Aim: The aim of this study was to evaluate the effect of Viscum album on angiogenic markers in A431 human skin cancer cells: In vitro. Cell Culture and Treatment: The skin cancer cell line, A431, was purchased from the National Centre for Cell Sciences, Pune, India, and cultured in Dulbecco's Modified Eagle's Medium supplemented with fetal bovine serum, penicillin G, and streptomycin. The cells were placed in 5% CO2 incubator and further experiments were started after the confluency stage was attained. The cells were incubated at 37°C with V. album (100 µg/ml) in a CO2 incubator. After 24 h treatment, matrix metalloproteinase (MMP-2), vascular endothelial growth factor (VEGF), phosphorylated Akt (p-Akt) and (β-catenin) proteins were studied in the A431 skin cancer cell line by western blot analysis. Results: A431 skin cancer cells showed a significant increase in the levels of MMP-2, VEGF, pAkt, and β-catenin, while V. album (100 µg/ml) treatment reduced the protein levels significantly. Conclusion: This study concludes that V. album shows anticancer potential by regulating angiogenic markers (MMP-2, VEGF, pAkt, and β-catenin) in A431 human skin cancer cells. Hence, V. album may be one of the therapeutic beneficial options for the treatment of skin cancer. [ABSTRACT FROM AUTHOR]