Search

Your search keyword '"Semenov, A. E."' showing total 1 results
Start Over Author "Semenov, A. E." Region puerto rico
1 results on '"Semenov, A. E."'

1. Synthesis and Antiviral Activity of Homodimers of 1,2,3-Triazolyl Nucleoside Analogues Based on Quinazoline-2,4-dione.

Author

Andreeva, O. V., Saifina, L. F., Shulaeva, M. M., Belenok, M. G., Garifullin, B. F., Zarubaev, V. V., Slita, A. V., Khabibulina, L. R., Aznagulov, R. F., Semenov, V. E., and Kataev, V. E.

Subjects
HOMODIMERS, LEAD compounds, COXSACKIEVIRUSES, NUCLEOSIDE derivatives, INFLUENZA, CLICK chemistry
Abstract

By covalent binding of 1,2,3-triazolyl nucleoside analogues by a polymethylene chain at the N3 atoms, a series of homodimers was synthesized, in which nucleic bases are replaced by quinazoline-2,4-dione moieties connected to the β-D-ribofuranose residues by 1,2,3-triazolylbutyl linkers. Screening of in vitro antiviral activity against influenza A (H1N1) and Coxsackie B3 viruses revealed a lead compound that showed high antiviral activity (IC50 = 11.6 μM) against influenza A/Puerto Rico/8/34 (H1N1) virus and a lead compound that exhibited high antiviral activity (IC50 = 12.2 μM) against enterovirus Coxsackie B3. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results