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A recent study from the University of Lisbon explores the spatial metabolomics of the liver, highlighting the zoned spatial variability and functional diversity of hepatocytes within hepatic lobules. The research discusses the distinct gene expression profiles, metabolic features, and regenerative capacity of hepatocytes in different lobule zones, emphasizing the potential of spatial metabolomics in understanding liver metabolic organization and disease. The study concludes with insights on future developments and applications of these technologies, offering a comprehensive overview of liver spatial metabolism. [Extracted from the article]