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Examine retention and evaluation of incorporating melanocortin-1 receptor genetic risk information materials in a skin cancer prevention intervention conducted in Hispanics living near Tampa, Florida and Ponce, Puerto Rico. Two researchers applied thematic content analysis to identify major themes of open-ended responses (n = 1689) from 489 participants. Five major thematic categories emerged: 1) intervention comments; 2) tips and tricks; 3) cancer prevention; 4) general information; and 5) risk factors and genetics. Responses captured under intervention comments (e.g., information was clear, easy to understand) and tips and tricks for sun protection (e.g., using sunscreen, wearing protective clothing) were most frequent. Participants noted the importance of conducting skin exams professionally or at home. English-preferring Tampa residents stated their individual risk factors, especially race and/or ethnicity, more frequently than Ponce residents and Spanish-preferring Tampa residents. Ponce residents were more likely to comment on wanting to share intervention materials with family and friends. Findings suggest Hispanic participants implemented sun safety activities. • The Hispanic community is a healthcare minority impacted by skin cancer disparities. • Skin cancer prevention in Hispanics living near Tampa, Florida and Puerto Rico. • Qualitative findings suggest materials were translated ensuring cultural relevance. [ABSTRACT FROM AUTHOR]