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Background: Geographic variation in the prevalence of isolated cleft lip with or without cleft palate may be due to exogenous environmental factors or genetic variation. In this study, we aim to evaluate the prevalence of isolated cleft lip with or without cleft palate in Polish urban and rural environments in order to identify geographic areas with high prevalence (defect clusters). Methods: We use all cases of congenital malformations reported to the Polish Registry of Congenital Malformations in the years 1998–2008 from the total population of 2,362,502 births. Results: We detect a strong signal of increased prevalence of isolated cleft lip with or without cleft palate in a single region of Poland, the Dolnośląskie voivodeship. Furthermore, we demonstrate a statistically significant prevalence differences between the urban and rural areas within this region. Through our comprehensive spatiotemporal analysis, we precisely define the cluster of the highest risk that comprises the eastern part of this voivodeship. [ABSTRACT FROM AUTHOR]

The study determined water temperature trends of rivers in Poland in the period 1971–2015, and also their spatial and temporal patterns. The analysis covered daily water temperature of 53 rivers recorded at 94 water gauge stations and air temperature at 43 meteorological stations. Average monthly, annual, seasonal and maximum annual tendencies of temperature change were calculated using the Mann–Kendall (M–K) test. Regional patterns of water temperature change were determined on the basis of Ward's hierarchical grouping for 16 correlation coefficients of average annual water temperature in successive 30-year sub-periods of the multi-annual period of 1971–2015. Moreover, regularities in monthly temperature trends in the annual cycle were identified using 12 monthly values obtained from the M–K Z test. The majority of average annual air and water temperature series demonstrate statistically significant positive trends. In three seasons: spring, summer and autumn, upward tendencies of temperature were detected at 70%–90% of the investigated water gauges. In 82% of the analysed rivers, similarity to the tendencies of change of monthly air temperature was concluded, with the climatic factor being recognised as of decisive importance for the changes in water thermal characteristics of the majority of rivers in Poland. In the winter months, positive trends of temperature were considerably weaker and in general statistically insignificant. On a regional scale, rivers with a quasi-natural thermal regime experienced temperature increases from April to November. In the other cases, different directions of change in river water temperature (RWT) were attributed to various forms of human impact. It was also found that for the majority of rivers the average annual water temperature in the analysed 30-year sub-periods displayed upward trends, statistically significant or close to the significance threshold. Stronger trends were observed in the periods after 1980, while a different nature of water temperature change was detected only in a couple of mountainous rivers or rivers transformed by human impact. In the beginning of the analysed period (1971–2015), the average annual water temperature of these rivers displayed positive and statistically significant trends, while after 1980 the trends were negative. The detected regularities and spatial patterns of water temperature change in rivers with a quasi-natural regime revealed a strong influence of climate on the modification of their thermal regime features. Rivers characterised by a clearly different nature of temperature change, both in terms of the direction of the tendencies observed and their statistical significance, were distinguished by alterations of water thermal characteristics caused by human activity. The results obtained may be useful in optimising the management of aquatic ecosystems, for which water temperature is a significant indicator of the ongoing environmental changes. [ABSTRACT FROM AUTHOR]