1. Cerebrospinal Fluid Amyloid-β Subtypes in Confirmed Frontotemporal Lobar Degeneration Cases: A Pilot Study.
- Author
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Verwey, Nicolaas A., Teunissen, Charlotte E., Hoozemans, Jeroen J.M., Rozemuller, Annemieke J.M., Scheltens, Philip, and Pijnenburg, Yolande A.L.
- Subjects
FRONTOTEMPORAL lobar degeneration ,CEREBROSPINAL fluid ,ALZHEIMER'S disease ,AMYOTROPHIC lateral sclerosis ,FRONTOTEMPORAL dementia ,PILOT projects - Abstract
To investigate amyloid-β (Aβ) in frontotemporal dementia (FTD), cerebrospinal fluid (CSF) Aβ38, Aβ40, and Aβ42 in frontotemporal lobar degeneration (FTLD; N = 18 genetically and/or pathologically confirmed and N = 8 FTD with concomitant amyotrophic lateral sclerosis) were compared with Alzheimer's disease (AD; pathological or Pittsburgh-compound-B Positron-emission-tomography (PIB-PET) positive; N = 25) and controls (N = 24). For all the Aβ subtypes, group difference was seen and post-hoc analysis revealed lower levels in FTLD compared to controls (p≤0.05). Aβ42/40 ratio showed no difference between FTLD and controls; however, a difference was seen between AD versus FTLD (p < 0.01). This is an intriguing finding, suggesting a possible role of Aβ in FTLD pathogenesis. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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