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The integration and processing of monitoring data in Historical Building Information Modeling (HBIM) can aid the design, restoration, and maintenance activities of historic buildings through the conscious assessment and potential improvement of their performance. In this regard, this paper presents a new methodology for performing structural performance and human-centric environmental comfort monitoring of historic buildings within the HBIM environment. A new Python-based software application, named H2BIM, developed by the authors to fully implement the proposed approach in Revit, i.e. the BIM design authoring platform by Autodesk, is also developed and implemented for the first time in this paper. The effectiveness of the novel methodology and developed software is demonstrated through an application case study involving a recently renewed historic building located in the countryside of Perugia, Italy, and subjected to various monitoring activities within the framework of GEOFIT Horizon 2020 Project. Obtained results highlight the multidisciplinarity and high interoperability of the new approach, whose employment via the developed software led to a comprehensive assessment of the building during its operating conditions. • A new methodology for structural performance and human-centric comfort monitoring in HBIM is proposed. • A Revit add-in application implementing the new methodology in HBIM is presented. • Multiphysics monitoring data are integrated and processed directly in HBIM. • An application case study is presented to demonstrate the effectiveness of the proposed methodology. • The performance of the case study building was evaluated during its service conditions. [ABSTRACT FROM AUTHOR]