1. Extended-spectrum β-lactamases and virulence factors in uropathogenic Escherichia coli in nursing homes in Lima, Peru.
- Author
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Gonzales-Rodriguez AO, Infante Varillas SF, Reyes-Farias CI, Ladines Fajardo CE, and Gonzales Escalante E
- Subjects
- Humans, Microbial Sensitivity Tests, Nursing Homes, Peru epidemiology, Virulence Factors genetics, beta-Lactamases genetics, Escherichia coli Infections epidemiology, Uropathogenic Escherichia coli genetics
- Abstract
Nursing homes are institutions with high prevalence of urinary tract infections caused by ESBL-producing E. coli with several virulence factors. The aim of this study was to determine the frequency of the bla CTX-M gene and eight virulence genes in 35 ESBL-producing uropathogenic E. coli from six nursing homes in Peru during 2018. Of the E. coli samples, 57.1% (20/35) were carriers of the bla CTX-M gene. Furthermore, we obtained frequencies of 46% (15/35) and 37% (13/35) for hly-alpha and cnf-1, respectively; we also found high presence of the iucC (63%, 22/35), aer (94%, 33/35) and chuA genes (94%, 33/34) as well as a frequency of 46% (16/35) and 91% (32/34) for the pap GII and nanA genes, respectively. The bla CTX-M gene is predominant and a high frequency of exotoxins gives it a competitive advantage for spreading into the bloodstream.
- Published
- 2022
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