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This article reports on results of the administration of the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) to 500 high school students (aged 16–19) in the Peruvian Amazon. Results indicate 68.6% of the sample reported consumption of alcohol in the past three months. One out of four students reported high risk involvement with at least one substance while 1 out of 3 reported moderate risk. This is one of the few instances in which ASSIST was administered to adolescents and offers possibilities for further reflection on drug use at early ages. [ABSTRACT FROM AUTHOR]

Research on psychedelic-assisted psychotherapy has shown that music affects therapeutic outcomes at a fundamental level. The development of such therapies calls for research on the use of music with consciousness-altering substances, especially in contexts informed by their traditional use. Informed by ethnographic reports, our project answers this call, investigating the phenomenology of listening to icaros (medicine songs) during ayahuasca ceremonies as reported by addiction rehabilitation patients at Peru's Centro Takiwasi. We found that icaros were therapeutically significant. They elicited experiences of healing by modulating patients' emotions and the altered state induced by ayahuasca. They helped patients feel safe while guiding them through difficult memories and emotions, and facilitating experiences of healing and learning about their addictions. Thus, similar therapies must carefully consider how they incorporate music in their protocols. We suggest further research to better understand the synergistic, therapeutic effects of music and altered states of consciousness, especially in cross-cultural environments. [ABSTRACT FROM AUTHOR]

The medicinal plant diet is a healing process used in traditional Amazonian medicine (TAM), and it is poorly described within the scientific literature. This work analyzes the experience of seven participants in this therapy performed at the Takiwasi Center in Peru. Semistructured interviews were performed before and after treatment, documenting participants' motivation, psychological experience, and perceived personal changes (physically, psychologically, socially, and spiritually), as well as the role played by each medicinal plant. All the interviews were recorded, transcribed, and analyzed using interpretative phenomenological analysis. Reasons to participate in the plant diet included self‐discovery, personal development, interest in plant medicine, and professional realization. The experience was perceived as intense and allowed participants to experience self‐acceptance, self‐discovery, mental balance, rest, cleansing, and connection with nature. Three months after the experience, participants felt physical changes (n = 6), psychological changes (n = 7), social changes (n = 5), and spiritual changes (n = 5). [ABSTRACT FROM AUTHOR]

Takiwasi is a therapeutic community for the treatment of Substance Use Disorders (SUDs) that combines traditional Amazonian medicine (TAM) with modern psychotherapy. One of the plant medicines from TAM used in this protocol is purgahuasca. It is a decoction of the vine Banisteriopsis caapi alone, whose use is traditional among the Awajún and other ethnic groups in Peru. The research began with a field trip to Awajún territory to explore the indigenous use of purgahuasca as an initiation rite. Then, analysis of its application was conducted in the clinical context of Takiwasi. Open-ended and semi-structured interviews with Awajún informants and Takiwasi's therapeutic staff were performed and analyzed following the narrative methodological approach. Further clinical data on the ingestion of purgahuasca by Takiwasi's SUD patients were obtained from the internal repository. These indicate that 359 (92.1%) patients reported having had the so-called mareación (dizziness), 299 (76.7%) experienced physical sensations, and 208 (53.3%) had visions. These effects can be related to the psychoactivity of β-Carbolines alkaloids from B. caapi, a medicinal plant that seems to have potential benefits also for SUD, especially giving a key contribution to the patients' therapeutic process of becoming aware of the personal reasons behind addictive behaviors. [ABSTRACT FROM AUTHOR]

The field of medical ethnobotany has historically contributed to the advancement of modern pharmaceutical and biomedical science through bringing discoveries from the field into the laboratory. In ethnopharmacology, a sub-field of ethnobotany, there is a concerning lack of ethnographic methods reported in the literature. The ethnographic approach is essential for detailing traditional methods of preparation and administration of plant medicines, yet pharmaceutical researchers overemphasize western epistemologies of medicinal discovery and production. In the present work, we propose an ethnopharmaceutical survey as a model to investigate the culturally recognized standards necessary for the formulation of herbal medicines. Fieldwork based on participant observation and semi-structured interviews examined the modes of preparation employed by traditional healers in the Amazonian region of San Martín, Peru. The authors draw on anthropological insight into plural epistemological encounters and propose an ethnopharmaceutical approach that takes seriously the Amazonian methods and perceptions for the preparation of traditional plant medicines. [ABSTRACT FROM AUTHOR]

The Peruvian Amazon holds more than 1000 plant species with commercial potential and the national sales of natural products derived from medicinal and aromatic plants have exceeded $ 400 million per year. Research and development activities carried out on the genetic and biochemical composition of Peruvian flora have to abide by national and international regulations, such as the Nagoya Protocol (NP). The aim of this paper is to describe the implications of the current implementation of the NP in Peru for performing research on national genetic resources. A review of the current legal framework and status of the NP in Peru was performed accompanied by first-hand experience undertaken by submitting a request for access to genetic resources related to wild continental species. So far, Peru has issued 16 Internationally Recognized Certificates of Compliance (IRCCs) through 2 of the identified National Authorities. Some of the difficulties and challenges observed have to do with the degree of effective implementation of the Access and Benefit-Sharing (ABS) system, the fact that the application process is not sufficiently clear, and the wide gap between this formal system and what occurs informally outside of it. In response to this, training and implementation projects have been launched and a new law on the access to genetic resources has been proposed. The difficulties observed still represent an obstacle to scientific research and the development of new commercial products based on Peruvian traditional knowledge and genetic resources. Although improvements have been made to the ABS framework, there remain major challenges to encouraging and ascertaining the equitable and sustainable use of Peru's biodiversity. Image 1 [ABSTRACT FROM AUTHOR]

Objective: Ayahuasca, an entheogen from the Amazon rainforest, has garnered growing interest for treating substance dependence. To date, there is little research concerning the act of ayahuasca-related purging (mainly vomiting), which is considered to be central to healing during ayahuasca rituals. This study explored practitioner perspectives on purging during ayahuasca rituals at the Takiwasi Center in Peru., Method: We conducted in-depth interviews with curanderos (healers), plant preparers, and psychotherapists ( N = 11) at the Takiwasi Center between August and October 2021. Interviews were conducted and transcribed in Spanish. Interviews were analyzed using a thematic analysis approach., Results: Participants described purging as a fluid concept that went beyond the act of vomiting. Participant narratives around purging were organized into three central themes or accounts: spiritual-oriented, which highlighted the relationship between purging and spiritual development; Amazonian-oriented, which emphasized purging as a cathartic expulsion of embodied cargas (loads) that are perceived to lead to sickness; and clinical-oriented, which stressed that purging generates a range of empirically observable therapeutic benefits. All of these explanatory models emphasized the pivotal interconnection between purging and healing during ayahuasca-assisted treatment for substance dependence at Takiwasi., Conclusions: This study highlights practitioner perspectives on purging at the Takiwasi Center, who offer three main explanatory models for this aspect of healing during ayahuasca-assisted therapy for substance dependence. This research contributes to the limited literature on the role of purging in ayahuasca-related healing, which may inform further investigation into differential understandings of the role of purging for therapeutic benefits.