1. Activity-guided isolation of novel norwithanolides from depreasubtriflora with potential cancer chemopreventive activity.
- Author
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Su BN, Park EJ, Nikolic D, Santarsiero BD, Mesecar AD, Vigo JS, Graham JG, Cabieses F, van Breemen RB, Fong HH, Farnsworth NR, Pezzuto JM, and Kinghorn AD
- Subjects
- Animals, Anticarcinogenic Agents, Carcinoma, Hepatocellular, Crystallography, X-Ray, Drug Screening Assays, Antitumor, Lactones chemistry, Lactones pharmacology, Mice, Molecular Conformation, Molecular Structure, NAD(P)H Dehydrogenase (Quinone) metabolism, Nuclear Magnetic Resonance, Biomolecular, Peru, Tumor Cells, Cultured drug effects, Lactones isolation & purification, Plants, Medicinal chemistry, Solanaceae chemistry
- Abstract
Activity-monitored fractionation of a CHCl(3)-soluble extract of Deprea subtriflora using a quinone reductase induction assay led to the purification of subtrifloralactones A-J (1-10), 10 novel C-18 norwithanolides based on a new C(27) skeleton. These compounds were characterized by spectroscopic and chemical studies, and single-crystal X-ray diffraction analysis was used to confirm the structures of 1 and 4. Compounds 1-10 were evaluated for their cancer chemopreventive activity in terms of their ability to induce quinone reductase activity with cultured murine hepatoma cells, and compounds 1 and 6 were found to be highly effective.
- Published
- 2003
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