1. New triterpene glycosides from the stems of Anomospermum grandifolium.
- Author
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Plaza A, Cinco M, Tubaro A, Pizza C, and Piacente S
- Subjects
- Ampicillin pharmacology, Antifungal Agents chemistry, Antifungal Agents pharmacology, Candida albicans drug effects, Enterococcus faecalis drug effects, Escherichia coli drug effects, Glycosides chemistry, Glycosides pharmacology, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Peru, Plant Stems chemistry, Pseudomonas aeruginosa drug effects, Staphylococcus aureus drug effects, Stereoisomerism, Triterpenes chemistry, Triterpenes pharmacology, Dammaranes, Antifungal Agents isolation & purification, Glycosides isolation & purification, Menispermaceae chemistry, Plants, Medicinal chemistry, Triterpenes isolation & purification
- Abstract
Two new dammarane saponins identified as jujubogenin 3-O-alpha-l-arabinofuranosyl(1-->2)-[beta-d-glucopyranosyl(1-->6) beta-d-glucopyranosyl(1-->3)]-alpha-l-arabinopyranoside (2) and jujubogenin 3-O-alpha-l-arabinofuranosyl(1-->2)-[6-O-[3-hydroxy-3-methylglutaryl]-beta-d-glucopyranosyl(1-->3)]-alpha-l-arabinopyranoside (3) and a new lupane saponin, 3beta-hydroxylup-20(29)-en-27,28-dioic acid 28-O-beta-d-glucopyranosyl(1-->2)-[beta-d-xylopyranosyl(1-->3)]-beta-d-xylopyranosyl(1-->2)-beta-d-glucopyranoside ester (5), along with the known jujubogenin 3-O-alpha-l-arabinofuranosyl(1-->2)-[beta-d-glucopyranosyl(1-->3)]-alpha-l-arabinopyranoside (1) and 3beta-hydroxylup-20(29)-ene-27,28-dioic acid (4), were isolated from the methanol extract of the stems of Anomospermum grandifolium. The structures of the new compounds were established by spectral analysis. Antimicrobial activity screening of compounds 1-3 revealed antifungal properties against C. albicans ATCC 3153 for compounds 2 and 3. The antibacterial and antifungal activities of the petroleum ether, chloroform, and methanol extracts of A. grandifolium stems were also evaluated.
- Published
- 2003
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