1. Tanacetum Parthenium (L.) Sch Bip From Peru: Antioxidant Profile and The Antinociceptive Effect in An Experimental Model.
- Author
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Herrera-Calderon, Oscar, Bulege-Gutiérrez, Wilfredo, Javier-Silva, Luz Alexandra, Iparraguirre-Meza, Melva, Guillermo Sanchez-Araujo, Victor, Julia Melgar-Merino, Elizabeth, Tinco-Jayo, Johnny Aldo, Santiago Almeida-Galindo, José, and Pari-Olarte, Josefa Bertha
- Subjects
PHYTOCHEMICALS ,STEROID saponins ,ETHANOL ,PHENOLS ,OXIDANT status ,FLOWER shows ,ANTIOXIDANTS ,SAPONINS - Abstract
Background: Tanacetum parthenium (L.) Sch Bip known as "santa maría" (Asteraceae family) is used in Peru for inflammatory diseases and also in colic, stomachache, headaches, diarrhea, among other. Objective: The aim was to determine the antioxidant profile, and analgesic effect of ethanolic extract of flowers and leaves of T. parthenium Material and Methods: Leaves and flowers of T. parthenium were soaked in 96% ethanol and the obtained extract was analyzed using chemical reactions for identifying each secondary metabolite, 2,2-Diphenyl-1-picrylhydrazyl (DPPH) was used to determine the antioxidant capacity, and the antinociceptive effect was determined by using tail flick method. Results: Qualitative phytochemical study indicates the presence phenolic compounds, alkaloids, flavonoids, saponins and steroids in both extracts. In DPPH assay IC50 showed in leaves and flowers extract 452.10 ± 10.2 µg/mL and 270.70 ± 20.6 µg/mL respectively. The antinociceptive effect was better in leaves at doses 300 mg/Kg than flower extract. Conclusions: The ethanolic extract of flowers of T. parthenium showed a high antioxidant activity and antinociceptive effect in mice. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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