1. The high mobility group I-C gene (HMGI-C): polymorphism and genetic localization.
- Author
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Ishwad CS, Shriver MD, Lassige DM, and Ferrell RE
- Subjects
- Black or African American, Black People genetics, Chromosome Mapping, DNA Primers, Gene Frequency, Genetic Linkage, Genetic Markers, HMGA2 Protein, High Mobility Group Proteins biosynthesis, Humans, Microsatellite Repeats, Nuclear Proteins genetics, Pedigree, Pennsylvania, Polymerase Chain Reaction, Recombination, Genetic, White People genetics, Chromosomes, Human, Pair 12, High Mobility Group Proteins genetics, Polymorphism, Genetic
- Abstract
We have identified a highly informative dinucleotide repeat in the 5'-flanking region of the human high mobility group I-C (HMGI-C) gene. This polymorphism consists of 18-37 copies of a (CT) repeat with an observed heterozygosity of 82-83% in African Americans and Caucasians. Linkage analysis in CEPH pedigrees localized the HMGI-C gene to chromosome region 12q13-15 with no recombination observed between HMCI-C and markers D12S102 and D12S8.
- Published
- 1997
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