1. Adverse Maternal Outcomes Differ between Obese and Nonobese Women with Severe Preeclampsia.
- Author
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Teefey CP, Durnwald CP, Srinivas SK, and Levine LD
- Subjects
- Administration, Intravenous statistics & numerical data, Adult, Body Mass Index, Female, Humans, Pennsylvania, Pregnancy, Pregnancy Outcome, Risk, Risk Assessment, Severity of Illness Index, Antihypertensive Agents administration & dosage, Obesity diagnosis, Obesity epidemiology, Obesity physiopathology, Pre-Eclampsia diagnosis, Pre-Eclampsia epidemiology, Pre-Eclampsia physiopathology, Pre-Eclampsia therapy, Pregnancy Complications diagnosis, Pregnancy Complications epidemiology, Pregnancy Complications etiology, Pregnancy Complications therapy
- Abstract
Objective: This article evaluates the differences in adverse maternal outcomes related to severe preeclampsia in obese versus nonobese women., Study Design: Retrospective cohort study and planned secondary analysis of women with severe preeclampsia comparing a composite adverse maternal outcome related to preeclampsia among obese (body mass index [BMI] ≥ 30 kg/m
2 ) and nonobese (BMI < 30 kg/m2 ) women. The composite outcome was defined as ≥ 1 of the following prior to discharge: renal failure, liver abnormality, thrombocytopenia, blood transfusion, pulmonary edema, disseminated intravascular coagulation, stroke, or eclampsia. Multivariable logistic regression was used to control for confounders., Results: Of the 152 women included, 37.5% were obese and 62.5% were nonobese. The prevalence of the primary outcome was 15.8% with obese women less likely to have the composite outcome compared with nonobese women (7% vs. 21.1%, p = 0.02). This remained after adjusting for confounders including maternal age, race, and chronic hypertension (adjusted odds ratio, 0.33 [0.12-0.89], p = 0.03). Obese women were, however, more likely to require intravenous antihypertensive medication peripartum compared with nonobese women (49.1% vs. 28.4%, p = 0.01)., Conclusion: Obese women with severe preeclampsia may have a different phenotype of severe preeclampsia that is more associated with severe hypertension rather than end-organ damage., Competing Interests: None., (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.)- Published
- 2019
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