This article reports that Jacques Werth, president of High Probability Selling, a sales training company based in Media, Pennsylvania, says he overcame the loneliness and depression experienced early in his career by preparing for trips well in advance and building up a good contact management system. Megan McDonough, a former national accounts manager for a large health care firm, who traveled the country at least once a week to negotiate million-dollar deals, recalls recognizing her own signs of depression. McDonough, who left her traveling sales job to start her own marketing company and write a book, Infinity in a Box: Using Yoga to Live With Ease, believes the most important thing that business travelers experiencing depression or loneliness can do for themselves is pay attention to the signs.