1. Leiomyosarcoma of the head and neck: A 17-year single institution experience and review of the National Cancer Data Base.
- Author
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Workman AD, Farquhar DR, Brody RM, Parasher AK, Carey RM, Purkey MT, Nagda DA, Brooks JS, Hartner LP, Brant JA, and Newman JG
- Subjects
- Adult, Aged, Aged, 80 and over, Cohort Studies, Databases, Factual, Disease-Free Survival, Female, Head and Neck Neoplasms diagnostic imaging, Head and Neck Neoplasms mortality, Hospitals, University, Humans, Kaplan-Meier Estimate, Leiomyosarcoma diagnostic imaging, Leiomyosarcoma mortality, Male, Middle Aged, Neck Dissection methods, Neoplasm Invasiveness pathology, Neoplasm Recurrence, Local mortality, Neoplasm Recurrence, Local therapy, Neoplasm Staging, Pennsylvania, Prognosis, Proportional Hazards Models, Radiotherapy, Adjuvant, Retrospective Studies, Risk Assessment, Survival Analysis, Head and Neck Neoplasms pathology, Head and Neck Neoplasms therapy, Leiomyosarcoma pathology, Leiomyosarcoma therapy, Neoplasm Recurrence, Local pathology
- Abstract
Background: Leiomyosarcoma is a rare neoplasm of the head and neck. The purpose of this study was to present our single-institution case series of head and neck leiomyosarcoma and a review of cases in the National Cancer Data Base (NCDB)., Methods: Patients with head and neck leiomyosarcoma at the University of Pennsylvania and in the NCDB were identified. Demographic characteristics, tumor factors, treatment paradigms, and outcomes were evaluated for prognostic significance., Results: Nine patients with head and neck leiomyosarcoma from the institution were identified; a majority had high-grade disease and cutaneous leiomyosarcoma, with a 5-year survival rate of 50%. Two hundred fifty-nine patients with leiomyosarcoma were found in the NCDB; macroscopic positive margins and high-grade disease were associated with poor prognosis (P < .01), and positive surgical margins were related to adjuvant radiation (P < .001)., Conclusion: Head and neck leiomyosarcoma presents at a high grade and is preferentially treated with surgery. Several demographic and tumor-specific factors are associated with outcomes and prognosis., (© 2017 Wiley Periodicals, Inc.)
- Published
- 2018
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