1. Scoparic acid A, a beta-glucuronidase inhibitor from Scoparia dulcis.
- Author
-
Hayashi T, Kawasaki M, Okamura K, Tamada Y, Morita N, Tezuka Y, Kikuchi T, Miwa Y, and Taga T
- Subjects
- Acetylation, Crystallization, Diterpenes isolation & purification, Diterpenes pharmacology, Magnetic Resonance Spectroscopy, Methylation, Molecular Conformation, Paraguay, X-Ray Diffraction, Diterpenes chemistry, Glucuronidase antagonists & inhibitors, Plants, Medicinal chemistry
- Abstract
The 70% EtOH extract of Scoparia dulcis showed inhibitory activity against beta-glucuronidase from bovine liver. Bioassay-directed fractionation of the active extract led to the isolation of three labdane-type diterpene acids, scoparic acid A [1] [6-benzoyl-12-hydroxy-labda-8(17), 13-dien-18-oic acid], scoparic acid B [2] [6-benzoyl-14,15-dinor-13-oxo-8(17)-labden-18-oic acid], and scoparic acid C [3] [6-benzoyl-15-nor-14-oxo-8(17)-labden-18-oic acid], the structures of which were established by spectral means, including X-ray analysis. Scoparic acid A was found to be a potent beta-glucuronidase inhibitor.
- Published
- 1992
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