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A preprint abstract from biorxiv.org discusses the role of two proteins, NUP210L and BAF-L, in ensuring microtubule organization and nuclear integrity in spermatids. These proteins are involved in various morphogenic processes during spermiogenesis, including nuclear elongation and chromatin compaction. While the individual inactivation of BAF-L or NUP210L in mice does not affect fertility, the double knockout of both proteins leads to spermatid arrest and mislocalization of nuclear pore complexes. The study suggests that the NPC array and chromatin play a crucial role in maintaining nuclear integrity during spermatid nuclear remodeling. However, it is important to note that this preprint has not undergone peer review. [Extracted from the article]

According to a preprint abstract, researchers have discovered that two proteins, NUP210L and BAF-L, play a crucial role in the fertility of mice. While the inactivation of either protein alone did not affect fertility, mice lacking both proteins were infertile. These mice experienced arrested spermatid development, with mislocalized nuclear pore complexes and disorganized manchette microtubules. The researchers suggest that these proteins are important for maintaining nuclear integrity during spermatid nuclear remodeling. This research has not yet undergone peer review. [Extracted from the article]