1. Mycoleptodiscins A and B, cytotoxic alkaloids from the endophytic fungus Mycoleptodiscus sp. F0194.
- Author
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Ortega HE, Graupner PR, Asai Y, Tendyke K, Qiu D, Shen YY, Rios N, Arnold AE, Coley PD, Kursar TA, Gerwick WH, and Cubilla-Rios L
- Subjects
- Alkaloids chemistry, Antineoplastic Agents chemistry, Drug Screening Assays, Antitumor, Humans, Inhibitory Concentration 50, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Panama, Spectrophotometry, Infrared, Alkaloids isolation & purification, Alkaloids pharmacology, Antineoplastic Agents isolation & purification, Antineoplastic Agents pharmacology, Ascomycota chemistry
- Abstract
Two novel reddish-orange alkaloids, mycoleptodiscin A (1) and mycoleptodiscin B (2), were isolated from liquid cultures of the endophytic fungus Mycoleptodiscus sp. that had been isolated from Desmotes incomparabilis in Panama. Elucidation of their structures was accomplished using 1D and 2D NMR spectroscopy in combination with IR spectroscopic and MS data. These compounds are indole-terpenes with a new skeleton uncommon in nature. Mycoleptodiscin B (2) was active in inhibiting the growth of cancer cell lines with IC50 values in the range 0.60-0.78 μM.
- Published
- 2013
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