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Two essential metal contaminations were studied in a total of sixty silver pomfret Pampus argenteus samples. The purpose of the current study was to evaluate the levels of Zn and Cu in the muscle tissues of the commercial species P. argenteus in the fishing harbour of Karachi, the most important in Pakistan, and to correlate the concentration of metals with respect to fish size. Moreover, this study sought to establish the potential risk to humans from consumption of fish samples contaminated with these heavy metals. Zn concentrations in the silver pomfret were higher than Cu. The ranges of Zn and Cu concentrations were found to be from 2 to 12 and 1 to 6 mg/kg dry wt., respectively. The differences in both Zn and Cu concentrations between seasons were statistically significant. These results can be used to provide baseline information for risk assessment associated with their consumption, as the Estimated Daily Intake (EDI) for the fish tissues and Zn and Cu levels were below the daily dietary allowance recommended by international standards. Therefore, it may be concluded that these metals should not pose any health threat to the consumers resulting from the consumption of the fish. The relationship between Zn and Cu levels and fish size (both length and weight) of the fish were minimal, indicating that metal concentration in fish tissues was independent of lengths and weights. [ABSTRACT FROM AUTHOR]